The series follows the romantic but unusual relationship of Akira Tsubaki and Mikoto Urabe. Urabe is a mysterious female transfer student who recently came to Tsubaki's high school. After a series of strange events, Tsubaki finds himself addicted to Urabe's drool. She claims the addiction to be "love sickness", and their relationship slowly progresses, focusing on the odd friendship and behavior that comes out of their " drool bond ".

The plot covers the various relationship developments for the couple, and how they're able to deal with, or overcome them via their special bond. Somehow, the drool allows them to experience what each other are thinking or feeling, and allows for a better understanding of each others emotions, more so than any other couple. However, because Tsubaki has never had a girlfriend, and Urabe has never had a boyfriend, and because they both declare to each other that they are virgins, they do like to take things very slowly, with intimate aspects of their relationship being experienced very carefully, many times by trial and error. This aspect of their mutual love, among many other quirky happenings, leaves the reader or viewer wondering when, or if, they will ever kiss.

Nevertheless, as the story progresses, the relationship between the two deepens into genuine, pure love. The manga strongly foreshadows that their souls will become deeply intertwined, that they will never break up, and that they will stay together and be committed to one another for life.

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